{"id":112600,"date":"2025-10-15T13:57:23","date_gmt":"2025-10-15T11:57:23","guid":{"rendered":"https:\/\/www.linseis.com\/nicht-kategorisiert\/aktif-farmasoetik-bilesenlerin-karakterizasyonu-icin-es-zamanli-termal-analiz\/"},"modified":"2026-01-23T10:37:36","modified_gmt":"2026-01-23T09:37:36","slug":"aktif-farmasoetik-bilesenlerin-karakterizasyonu-icin-es-zamanli-termal-analiz","status":"publish","type":"post","link":"https:\/\/www.linseis.com\/tr\/bilgi\/aktif-farmasoetik-bilesenlerin-karakterizasyonu-icin-es-zamanli-termal-analiz\/","title":{"rendered":"Aktif farmas\u00f6tik bile\u015fenlerin karakterizasyonu i\u00e7in e\u015f zamanl\u0131 termal analiz"},"content":{"rendered":"\t\t<div data-elementor-type=\"wp-post\" data-elementor-id=\"112600\" class=\"elementor elementor-112600 elementor-105587\" data-elementor-post-type=\"post\">\n\t\t\t\t<div class=\"elementor-element elementor-element-7926ba2 e-flex e-con-boxed e-con e-parent\" data-id=\"7926ba2\" data-element_type=\"container\" data-e-type=\"container\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t<div class=\"elementor-element elementor-element-127df63 e-con-full e-flex e-con e-child\" data-id=\"127df63\" data-element_type=\"container\" data-e-type=\"container\">\n\t\t\t\t<div class=\"elementor-element elementor-element-37f7e19 elementor-widget elementor-widget-html\" data-id=\"37f7e19\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"html.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<script type=\"application\/ld+json\">{\r\n  \"@context\": \"https:\/\/schema.org\",\r\n  \"@type\": \"FAQPage\",\r\n  \"mainEntity\": [{\r\n    \"@type\": \"Question\",\r\n    \"name\": \"Was erm\u00f6glicht die Methodenkombination der Simultanen Thermischen Analyse (STA)?\",\r\n    \"acceptedAnswer\": {\r\n      \"@type\": \"Answer\",\r\n      \"text\": \"Diese Methodenkombination erm\u00f6glicht es, Masse\u00e4nderungen und kalorische Effekte simultan an derselben Probe zu erfassen, wodurch eine direkte Korrelation der Ergebnisse ohne die Unsicherheiten getrennter Messungen m\u00f6glich wird.\"\r\n    }\r\n  },{\r\n    \"@type\": \"Question\",\r\n    \"name\": \"Was erkennt die DSC-Komponente der Simultanen Thermischen Analyse (STA)?\",\r\n    \"acceptedAnswer\": {\r\n      \"@type\": \"Answer\",\r\n      \"text\": \"Die DSC-Komponente der STA erkennt diese \u00dcberg\u00e4nge als charakteristische endotherme oder exotherme Peaks, w\u00e4hrend die TG-Kurve korrespondierende Masseverluste dokumentiert.\"\r\n    }\r\n  },{\r\n    \"@type\": \"Question\",\r\n    \"name\": \"Was erm\u00f6glicht die Simultane Thermische Analyse (STA) bei der Untersuchung der thermischen Zersetzung pharmazeutischer Wirkstoffe?\",\r\n    \"acceptedAnswer\": {\r\n      \"@type\": \"Answer\",\r\n      \"text\": \"Die Simultane Thermische Analyse (STA) erm\u00f6glicht die fr\u00fchzeitige Identifikation solcher Prozesse durch die gleichzeitige Erfassung von Masse\u00e4nderungen sowie endothermen und exothermen Effekten.\"\r\n    }\r\n  }]\r\n}\r\n<\/script>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-8f8b21d elementor-toc--minimized-on-tablet elementor-widget elementor-widget-table-of-contents\" data-id=\"8f8b21d\" data-element_type=\"widget\" data-e-type=\"widget\" data-settings=\"{&quot;headings_by_tags&quot;:[&quot;h2&quot;],&quot;exclude_headings_by_selector&quot;:[],&quot;no_headings_message&quot;:&quot;No headings were found on this 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9.335-24.544 9.317-33.901-.04l-22.667-22.667c-9.373-9.373-9.373-24.569 0-33.941L207.03 130.525c9.372-9.373 24.568-9.373 33.941-.001z\"><\/path><\/svg><\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<div id=\"elementor-toc__8f8b21d\" class=\"elementor-toc__body\">\n\t\t\t<div class=\"elementor-toc__spinner-container\">\n\t\t\t\t<svg class=\"elementor-toc__spinner eicon-animation-spin e-font-icon-svg e-eicon-loading\" aria-hidden=\"true\" viewBox=\"0 0 1000 1000\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\"><path d=\"M500 975V858C696 858 858 696 858 500S696 142 500 142 142 304 142 500H25C25 237 238 25 500 25S975 237 975 500 763 975 500 975Z\"><\/path><\/svg>\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-87bd1e3 elementor-widget elementor-widget-spacer\" data-id=\"87bd1e3\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"spacer.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<div class=\"elementor-spacer\">\n\t\t\t<div class=\"elementor-spacer-inner\"><\/div>\n\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-746ad39 elementor-widget elementor-widget-text-editor\" data-id=\"746ad39\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p>\u0130la\u00e7 end\u00fcstrisi, aktif farmas\u00f6tik bile\u015fenlerin stabilitesini ve termal davran\u0131\u015f\u0131n\u0131 hassas bir \u015fekilde de\u011ferlendirmek gibi s\u00fcrekli bir zorlukla kar\u015f\u0131 kar\u015f\u0131yad\u0131r. \u00d6zellikle kat\u0131 veya kristal formdaki API&#8217;ler (farmas\u00f6tik olarak aktif bile\u015fenler) i\u00e7in termal analizin \u00f6nemli bir y\u00f6ntem oldu\u011fu kan\u0131tlanm\u0131\u015ft\u0131r.<a href=\"https:\/\/www.linseis.com\/tr\/\" data-auto-event-observed=\"true\" style=\"\"><b> termal anali\u0307z<\/b><\/a><a href=\"https:\/\/www.linseis.com\/tr\/\" data-auto-event-observed=\"true\" style=\"\"><b>e<\/b><\/a> vazge\u00e7ilmez bir ara\u00e7 olarak kendini kan\u0131tlam\u0131\u015ft\u0131r. <a href=\"https:\/\/www.linseis.com\/methoden\/thermogravimetrie\/\" data-auto-event-observed=\"true\"><strong>Termogravimetri (TG)<\/strong><\/a> ve dinamik <a href=\"https:\/\/www.linseis.com\/messgeraete\/dsc-dynamische-differenz-kalorimetrie\/\" data-auto-event-observed=\"true\"><strong>diferansiyel taramal\u0131 kalorimetri (DSC)<\/strong><\/a> tek bir analiz ad\u0131m\u0131nda. Bu y\u00f6ntem kombinasyonu, k\u00fctle de\u011fi\u015fimlerini ve kalorifik etkileri ayn\u0131 numune \u00fczerinde e\u015f zamanl\u0131 olarak kaydetmeyi m\u00fcmk\u00fcn k\u0131larak, ayr\u0131 \u00f6l\u00e7\u00fcmlerin belirsizlikleri olmadan sonu\u00e7lar\u0131n do\u011frudan korelasyonunu sa\u011flar. \u00d6zellikle y\u00fcksek kaliteli aktif farmas\u00f6tik bile\u015fenlerin ara\u015ft\u0131r\u0131lmas\u0131 ve geli\u015ftirilmesinde s\u0131kl\u0131kla oldu\u011fu gibi numune miktarlar\u0131 s\u0131n\u0131rl\u0131 oldu\u011funda <g id=\"gid_8\"><g id=\"gid_9\">STA<\/g><\/g> karma\u015f\u0131k farmas\u00f6tik sistemlerin neredeyse eksiksiz bir \u015fekilde karakterize edilmesini sa\u011flar. Her iki analiz de ayn\u0131 atmosfer, s\u0131cakl\u0131k kontrol\u00fc ve \u0131s\u0131tma h\u0131z\u0131 gibi tamamen ayn\u0131 ko\u015fullar alt\u0131nda ger\u00e7ekle\u015ftirildi\u011finden, STA kalite kontrol ve geli\u015ftirme i\u00e7in son derece tekrarlanabilir ve g\u00fcvenilir veriler sa\u011flar.    &nbsp;<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-91f5ddb elementor-widget elementor-widget-spacer\" data-id=\"91f5ddb\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"spacer.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<div class=\"elementor-spacer\">\n\t\t\t<div class=\"elementor-spacer-inner\"><\/div>\n\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-32825a9 elementor-widget elementor-widget-heading\" data-id=\"32825a9\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<h2 class=\"elementor-heading-title elementor-size-default\">Kritik ge\u00e7i\u015f noktalar\u0131n\u0131n belirlenmesi<\/h2>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-0ae2230 elementor-widget elementor-widget-text-editor\" data-id=\"0ae2230\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p>Bu <a href=\"https:\/\/www.linseis.com\/messgeraete\/thermische-analyse\/sta-simultane-thermische-analyse\/\"><strong>E\u015fzamanl\u0131 Termal Analiz (STA)<\/strong><\/a> farmas\u00f6tik geli\u015ftirme ve kalite kontrol i\u00e7in b\u00fcy\u00fck \u00f6nem ta\u015f\u0131yan kritik termal ge\u00e7i\u015f noktalar\u0131n\u0131 belirlemek i\u00e7in anahtar bir y\u00f6ntemdir.<\/p><p>Bu ge\u00e7i\u015f noktalar\u0131, farmas\u00f6tik olarak aktif maddelerin (API) i\u015fleme ko\u015fullar\u0131n\u0131 ve depolama stabilitesini \u00f6nemli \u00f6l\u00e7\u00fcde belirler.<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-d9546bc elementor-widget elementor-widget-spacer\" data-id=\"d9546bc\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"spacer.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<div class=\"elementor-spacer\">\n\t\t\t<div class=\"elementor-spacer-inner\"><\/div>\n\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-6f1120d elementor-widget elementor-widget-text-editor\" data-id=\"6f1120d\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p><strong>Anahtar ge\u00e7i\u015f noktalar\u0131:<\/strong><\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-feb266b elementor-widget elementor-widget-spacer\" data-id=\"feb266b\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"spacer.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<div class=\"elementor-spacer\">\n\t\t\t<div class=\"elementor-spacer-inner\"><\/div>\n\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-ad12dcf elementor-widget elementor-widget-text-editor\" data-id=\"ad12dcf\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<ul><li><a href=\"https:\/\/www.linseis.com\/wissen\/schmelzpunkt-kristallisation-und-glasuebergang-bei-polymeren\/\"><strong>Erime noktas\u0131:<\/strong><\/a> Aktif bile\u015fenlerin i\u015flenmesi ve depolanmas\u0131 i\u00e7in \u00e7ok \u00f6nemlidir.<\/li><li><a href=\"https:\/\/www.linseis.com\/wissen\/glasuebergangstemperatur\/\"><strong>Cams\u0131 ge\u00e7i\u015f s\u0131cakl\u0131\u011f\u0131 (Tg):<\/strong><\/a> Amorf veya yar\u0131-kristal maddelerin yumu\u015fad\u0131\u011f\u0131 s\u0131cakl\u0131k aral\u0131\u011f\u0131n\u0131 tan\u0131mlar. Kararl\u0131, kat\u0131 g\u00f6r\u00fcn\u00fcm\u00fcn kayboldu\u011fu ve bu nedenle depolama g\u00fcvenli\u011finin bozulabilece\u011fi s\u0131n\u0131r\u0131 karakterize eder. <\/li><li><strong>Bozunma s\u0131cakl\u0131\u011f\u0131:<\/strong> Kararl\u0131 proses ve depolama s\u0131cakl\u0131klar\u0131 olu\u015fturmak i\u00e7in ba\u015flang\u0131\u00e7 s\u0131cakl\u0131\u011f\u0131n\u0131n hassas bir \u015fekilde belirlenmesi.<\/li><li><a href=\"https:\/\/www.linseis.com\/wissen\/phasenuebergang-eines-stoffs-schmelzen\/\"><strong>Faz ge\u00e7i\u015fleri:<\/strong><\/a> Belirli erime veya d\u00f6n\u00fc\u015f\u00fcm s\u0131cakl\u0131klar\u0131 temelinde polimorfik kristal formlar\u0131n\u0131n karakterizasyonu.<\/li><\/ul>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-8ccab27 elementor-widget elementor-widget-spacer\" data-id=\"8ccab27\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"spacer.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<div class=\"elementor-spacer\">\n\t\t\t<div class=\"elementor-spacer-inner\"><\/div>\n\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-4ae71fb elementor-widget elementor-widget-text-editor\" data-id=\"4ae71fb\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p>STA&#8217;n\u0131n DSC bile\u015feni bu ge\u00e7i\u015fleri karakteristik endotermik veya ekzotermik pikler olarak tan\u0131rken, TG e\u011frisi kar\u015f\u0131l\u0131k gelen k\u00fctle kay\u0131plar\u0131n\u0131 belgelemektedir. Bir azalma <g id=\"gid_0\"><g id=\"gid_1\">cam ge\u00e7i\u015f s\u0131cakl\u0131\u011f\u0131<\/g><\/g>\u00d6rne\u011fin nem emilimi, istenmeyen faz d\u00f6n\u00fc\u015f\u00fcmlerine veya yeniden kristalle\u015fmeye yol a\u00e7abilir. <g id=\"gid_2\"><g id=\"gid_3\">yeniden kristalle\u015fme<\/g><\/g> yeniden kristalle\u015fme. Bu da kristal yap\u0131y\u0131 de\u011fi\u015ftirebilir &#8211; etkinlik kayb\u0131, de\u011fi\u015fen biyoyararlan\u0131m veya en basit durumda preparat\u0131n yeniden s\u0131n\u0131fland\u0131r\u0131lmas\u0131 ve yeniden etiketlenmesi ihtiyac\u0131 gibi olas\u0131 sonu\u00e7larla birlikte.  <\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-e8460c5 elementor-widget elementor-widget-heading\" data-id=\"e8460c5\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<h2 class=\"elementor-heading-title elementor-size-default\">Nem hassasiyetinin de\u011ferlendirilmesi  <\/h2>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-86c6ec4 elementor-widget elementor-widget-text-editor\" data-id=\"86c6ec4\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p>Bir\u00e7ok aktif farmas\u00f6tik bile\u015fen belirgin higroskopik davran\u0131\u015f sergiler, bu nedenle ba\u011f\u0131l nemdeki k\u00fc\u00e7\u00fck de\u011fi\u015fiklikler bile su emilimini ve dolay\u0131s\u0131yla stabiliteyi \u00f6nemli \u00f6l\u00e7\u00fcde etkileyebilir. Bu <a href=\"https:\/\/www.linseis.com\/messgeraete\/thermische-analyse\/sta-simultane-thermische-analyse\/\"><strong>STA<\/strong><\/a> buharla\u015fma veya kristalle\u015fme suyu yoluyla nem kayb\u0131n\u0131n nicel olarak belirlenmesini sa\u011flar (1). <\/p><p>Nem duyarl\u0131l\u0131\u011f\u0131n\u0131n analiz edilmesi, stabilite de\u011ferlendirmesi i\u00e7in gerekli olan birka\u00e7 kritik parametreyi i\u00e7erir. Suyun adsorpsiyonu ve desorpsiyonu, TG sinyalinde ayr\u0131k k\u00fctle de\u011fi\u015fiklikleri olarak g\u00f6r\u00fcn\u00fcr hale gelirken, e\u015flik eden \u0131s\u0131 veya s\u0131cakl\u0131k de\u011fi\u015fiklikleri suyun ba\u011flanma bi\u00e7imi hakk\u0131nda sonu\u00e7lar \u00e7\u0131kar\u0131lmas\u0131na olanak tan\u0131r.   <\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-5892926 elementor-widget elementor-widget-spacer\" data-id=\"5892926\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"spacer.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<div class=\"elementor-spacer\">\n\t\t\t<div class=\"elementor-spacer-inner\"><\/div>\n\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-a91c7c5 elementor-widget elementor-widget-text-editor\" data-id=\"a91c7c5\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p><strong>\u00d6nemli de\u011ferleme parametreleri:  <\/strong><\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-e6a997e elementor-widget elementor-widget-spacer\" data-id=\"e6a997e\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"spacer.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<div class=\"elementor-spacer\">\n\t\t\t<div class=\"elementor-spacer-inner\"><\/div>\n\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-c060447 elementor-widget elementor-widget-text-editor\" data-id=\"c060447\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<ul><li>Su emme kapasitesi: emilen su miktar\u0131n\u0131n numune k\u00fctlesine oran\u0131  <\/li><li>Denge nem i\u00e7eri\u011fi: tan\u0131mlanm\u0131\u015f ko\u015fullar alt\u0131nda nem dengesi durumu  <\/li><\/ul><ul><li>Sorpsiyon-desorpsiyon izotermleri: Nem miktar\u0131 ve ba\u011f\u0131l nem aras\u0131ndaki ili\u015fki  <\/li><\/ul><ul><li>Kristal su i\u00e7eri\u011fi: yap\u0131sal olarak ba\u011fl\u0131 su oran\u0131  <\/li><\/ul><ul><li>Nem emiliminin kineti\u011fi: su emilim\/serbest b\u0131rakma oran\u0131 Amorf API kristallerinde nem emilimi, cams\u0131 ge\u00e7i\u015f s\u0131cakl\u0131\u011f\u0131n\u0131n d\u00fc\u015fmesine yol a\u00e7ar ve bu da depolama veya ta\u015f\u0131ma s\u0131ras\u0131nda yeniden kristalle\u015fme e\u011filiminin artt\u0131\u011f\u0131 bir alanla sonu\u00e7lanabilir (2).  <\/li><\/ul>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-80a57bd elementor-widget elementor-widget-spacer\" data-id=\"80a57bd\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"spacer.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<div class=\"elementor-spacer\">\n\t\t\t<div class=\"elementor-spacer-inner\"><\/div>\n\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-e50a5e9 elementor-widget elementor-widget-image\" data-id=\"e50a5e9\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"image.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<img fetchpriority=\"high\" decoding=\"async\" width=\"800\" height=\"450\" src=\"https:\/\/www.linseis.com\/wp-content\/uploads\/2025\/10\/195-1024x576.png\" class=\"attachment-large size-large wp-image-112601\" alt=\"\" srcset=\"https:\/\/www.linseis.com\/wp-content\/uploads\/2025\/10\/195-1024x576.png 1024w, https:\/\/www.linseis.com\/wp-content\/uploads\/2025\/10\/195-300x169.png 300w, https:\/\/www.linseis.com\/wp-content\/uploads\/2025\/10\/195-768x432.png 768w, https:\/\/www.linseis.com\/wp-content\/uploads\/2025\/10\/195.png 1140w\" sizes=\"(max-width: 800px) 100vw, 800px\" \/>\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-f30a374 elementor-widget elementor-widget-heading\" data-id=\"f30a374\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<h2 class=\"elementor-heading-title elementor-size-default\">Termal ayr\u0131\u015fma ve depolama kararl\u0131l\u0131\u011f\u0131<\/h2>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-527dd88 elementor-widget elementor-widget-text-editor\" data-id=\"527dd88\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p>Termal ayr\u0131\u015fma, kimyasal b\u00fct\u00fcnl\u00fc\u011f\u00fc ve dolay\u0131s\u0131yla etkinli\u011fi do\u011frudan etkileyebilece\u011finden, aktif farmas\u00f6tik bile\u015fenlerin depolama stabilitesi \u00fczerinde belirleyici bir etkiye sahiptir. Bu <a href=\"https:\/\/www.linseis.com\/messgeraete\/thermische-analyse\/sta-simultane-thermische-analyse\/\"><strong>E\u015fzamanl\u0131 Termal Analiz (STA)<\/strong> <\/a>k\u00fctle de\u011fi\u015fikliklerinin yan\u0131 s\u0131ra endotermik ve ekzotermik etkilerin e\u015fzamanl\u0131 tespiti yoluyla bu t\u00fcr s\u00fcre\u00e7lerin erken tan\u0131mlanmas\u0131n\u0131 sa\u011flar. <\/p><p>Klasik termal ayr\u0131\u015fmaya ek olarak, <strong>oksidasyon reaksiyonlar\u0131<\/strong> da merkezi bir rol oynayabilir. Bunlar genellikle oksijen molek\u00fcler yap\u0131ya dahil oldu\u011fu i\u00e7in <strong>k\u00fctlenin artmas\u0131na<\/strong> yol a\u00e7ar. K\u0131smi oksidasyon bile kimyasal yap\u0131y\u0131 de\u011fi\u015ftirebilir ve b\u00f6ylece farmakolojik etkiyi bozabilir &#8211; genellikle ger\u00e7ek ayr\u0131\u015fma meydana gelmeden \u00e7ok \u00f6nce.  <\/p><p>Bir di\u011fer kritik fakt\u00f6r de <strong>denat\u00fcrasyondur<\/strong>: termal veya oksidatif etkiler \u00f6zellikle biyoteknolojik olarak \u00fcretilen veya protein bazl\u0131 aktif bile\u015fenlerin do\u011fal yap\u0131lar\u0131n\u0131 kaybetmelerine neden olur. Bu durum aktivite kayb\u0131na, agregat olu\u015fumuna veya sal\u0131n\u0131m\u0131n de\u011fi\u015fmesine yol a\u00e7abilir ve dolay\u0131s\u0131yla preparat\u0131n stabilitesi \u00fczerinde b\u00fcy\u00fck bir etkiye sahip olabilir. <\/p><p>Bozulma veya denat\u00fcrasyonun <strong>ba\u015flang\u0131\u00e7 s\u0131cakl\u0131\u011f\u0131n\u0131n<\/strong> kesin olarak belirlenmesi, depolama, ta\u015f\u0131ma ve i\u015fleme i\u00e7in \u00fcst s\u0131n\u0131r\u0131 tan\u0131mlad\u0131\u011f\u0131ndan ara\u015ft\u0131rma ve kalite kontrol i\u00e7in gereklidir. K\u0131sa s\u00fcreli a\u015f\u0131mlar bile geri d\u00f6n\u00fc\u015f\u00fc olmayan yap\u0131sal de\u011fi\u015fikliklere neden olabilir. Yard\u0131mlar\u0131 ile <a href=\"https:\/\/www.linseis.com\/messgeraete\/thermische-analyse\/sta-simultane-thermische-analyse\/\"><strong>STA<\/strong><\/a> ve ilgili kinetik modelleme sayesinde, bir ila\u00e7 maddesinin raf \u00f6mr\u00fc de tan\u0131mlanm\u0131\u015f saklama ko\u015fullar\u0131 alt\u0131nda g\u00fcvenilir bir \u015fekilde tahmin edilebilir.  <\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-52d2ade elementor-widget elementor-widget-spacer\" data-id=\"52d2ade\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"spacer.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<div class=\"elementor-spacer\">\n\t\t\t<div class=\"elementor-spacer-inner\"><\/div>\n\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-a3d7a0a elementor-widget elementor-widget-text-editor\" data-id=\"a3d7a0a\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p><strong>Depolama kararl\u0131l\u0131\u011f\u0131 \u00fczerindeki etkiler:<\/strong><\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-165ebb2 elementor-widget elementor-widget-spacer\" data-id=\"165ebb2\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"spacer.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<div class=\"elementor-spacer\">\n\t\t\t<div class=\"elementor-spacer-inner\"><\/div>\n\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-af87035 elementor-widget elementor-widget-text-editor\" data-id=\"af87035\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<ul><li><strong>Bozulma ve etkinlik kayb\u0131:<\/strong> kimyasal ayr\u0131\u015fma veya denat\u00fcrasyon nedeniyle aktif bile\u015fen konsantrasyonunda azalma<\/li><li><a href=\"https:\/\/www.linseis.com\/wissen\/oxidationsinduktionszeit-und-temperatur\/\"><strong>Oksidasyon:<\/strong><\/a> Oksijen kat\u0131l\u0131m\u0131 nedeniyle k\u00fctle art\u0131\u015f\u0131 ve yap\u0131sal de\u011fi\u015fim<\/li><li><strong>Bozunma \u00fcr\u00fcnlerinin olu\u015fumu:<\/strong> Kimyasal veya toksikolojik olarak ilgili yan \u00fcr\u00fcnlerin olu\u015fumu<\/li><li><strong>Nem ile etkile\u015fim:<\/strong> Artan nem ile termal stabilitede azalma ve olas\u0131 hidroliz s\u00fcre\u00e7leri<\/li><li><strong>Uzun vadeli prognoz:<\/strong> termokinetik modelleme kullan\u0131larak tan\u0131mlanm\u0131\u015f ko\u015fullar alt\u0131nda raf \u00f6mr\u00fcn\u00fcn tahmini<\/li><\/ul>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-abf69aa elementor-widget elementor-widget-spacer\" data-id=\"abf69aa\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"spacer.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<div class=\"elementor-spacer\">\n\t\t\t<div class=\"elementor-spacer-inner\"><\/div>\n\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-02c72d4 elementor-widget elementor-widget-heading\" data-id=\"02c72d4\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<h2 class=\"elementor-heading-title elementor-size-default\">Sonu\u00e7 <\/h2>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-edec17c elementor-widget elementor-widget-text-editor\" data-id=\"edec17c\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p>Bu <a href=\"https:\/\/www.linseis.com\/wissen\/oxidationsinduktionszeit-und-temperatur\/\"><strong>E\u015fzamanl\u0131 Termal Analiz<\/strong><\/a> ila\u00e7 end\u00fcstrisindeki laboratuvarlara, ara\u015ft\u0131rmac\u0131lara ve m\u00fchendislere son derece hassas, tekrarlanabilir ve zaman a\u00e7\u0131s\u0131ndan verimli bir ara\u00e7 sa\u011flar. API kristallerinin nem duyarl\u0131l\u0131\u011f\u0131n\u0131n, termal ge\u00e7i\u015flerinin ve ayr\u0131\u015fma s\u00fcre\u00e7lerinin derinlemesine ve g\u00fcvenilir bir \u015fekilde de\u011ferlendirilmesini sa\u011flar. \u00d6zellikle GMP ko\u015fullar\u0131 alt\u0131nda ve kalite g\u00fcvencesi ba\u011flam\u0131nda STA, API&#8217;lerin en y\u00fcksek bilimsel d\u00fczeyde geli\u015ftirilmesini ve depolanmas\u0131n\u0131 sa\u011flar. Y\u00f6ntem, kritik ge\u00e7i\u015f noktalar\u0131n\u0131n hassas bir \u015fekilde tan\u0131mlanmas\u0131n\u0131, nem hassasiyetinin g\u00fcvenilir bir \u015fekilde de\u011ferlendirilmesini ve termal ve kimyasal-yap\u0131sal bozunma davran\u0131\u015f\u0131n\u0131n eksiksiz bir \u015fekilde karakterize edilmesini sa\u011flar. Bu da hem etken madde analizinin g\u00fcvenli\u011fini hem de geli\u015ftirme, kalite kontrol ve stabilite testlerinin verimlili\u011fini \u00f6nemli \u00f6l\u00e7\u00fcde art\u0131r\u0131r.      <\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-06558f7 elementor-widget elementor-widget-spacer\" data-id=\"06558f7\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"spacer.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<div class=\"elementor-spacer\">\n\t\t\t<div class=\"elementor-spacer-inner\"><\/div>\n\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-227a35e elementor-widget elementor-widget-spacer\" data-id=\"227a35e\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"spacer.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<div class=\"elementor-spacer\">\n\t\t\t<div class=\"elementor-spacer-inner\"><\/div>\n\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-b97a285 elementor-widget elementor-widget-text-editor\" data-id=\"b97a285\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p><strong>Kaynaklar\u0131n listesi<\/strong> <\/p><p>(1) DocCheck Flexikon: Farmas\u00f6tik kristallerin stabilitesi.<\/p><p><a href=\"https:\/\/flexikon.doccheck.com\/de\/Stabilit%C3%A4tspr%C3%BCfung_(Pharmazie)\" target=\"_blank\" rel=\"noopener\">https:\/\/flexikon.doccheck.com\/de\/Stabilit%C3%A4tspr%C3%BCfung_(Eczane)<\/a><\/p><p>(2) Deutsche Apotheker Zeitung: Ayr\u0131\u015fma reaksiyonlar\u0131nda ustala\u015fmak.<\/p><p>h<a href=\"https:\/\/www.deutsche-apotheker-zeitung.de\/daz-az\/2015\/daz-52-2015\/zersetzungs-reaktionen-beherrschen\" target=\"_blank\" rel=\"noopener\">ttps:\/\/<\/a>www.deutsche-apotheker-zeitung.de\/daz-az\/2015\/daz-52-2015\/zersetzungs-reaktionen-beherrschen  <\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-0796c93 elementor-widget elementor-widget-spacer\" data-id=\"0796c93\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"spacer.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<div class=\"elementor-spacer\">\n\t\t\t<div class=\"elementor-spacer-inner\"><\/div>\n\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t","protected":false},"excerpt":{"rendered":"<p>\u0130la\u00e7 end\u00fcstrisi, aktif bile\u015fenlerin stabilitesini ve termal davran\u0131\u015f\u0131n\u0131 hassas bir \u015fekilde de\u011ferlendirme konusunda s\u00fcrekli bir zorlukla kar\u015f\u0131 kar\u015f\u0131yad\u0131r<\/p>\n","protected":false},"author":15,"featured_media":112602,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"inline_featured_image":false,"footnotes":""},"categories":[754],"tags":[],"class_list":["post-112600","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-bilgi"],"acf":[],"_links":{"self":[{"href":"https:\/\/www.linseis.com\/tr\/wp-json\/wp\/v2\/posts\/112600","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.linseis.com\/tr\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.linseis.com\/tr\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.linseis.com\/tr\/wp-json\/wp\/v2\/users\/15"}],"replies":[{"embeddable":true,"href":"https:\/\/www.linseis.com\/tr\/wp-json\/wp\/v2\/comments?post=112600"}],"version-history":[{"count":0,"href":"https:\/\/www.linseis.com\/tr\/wp-json\/wp\/v2\/posts\/112600\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.linseis.com\/tr\/wp-json\/wp\/v2\/media\/112602"}],"wp:attachment":[{"href":"https:\/\/www.linseis.com\/tr\/wp-json\/wp\/v2\/media?parent=112600"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.linseis.com\/tr\/wp-json\/wp\/v2\/categories?post=112600"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.linseis.com\/tr\/wp-json\/wp\/v2\/tags?post=112600"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}