{"id":105918,"date":"2025-10-15T13:57:23","date_gmt":"2025-10-15T11:57:23","guid":{"rendered":"https:\/\/www.linseis.com\/sem-categoria\/analise-termica-simultanea-para-a-caraterizacao-de-ingredientes-farmaceuticos-activos\/"},"modified":"2026-01-12T09:23:24","modified_gmt":"2026-01-12T08:23:24","slug":"analise-termica-simultanea-para-a-caraterizacao-de-ingredientes-farmaceuticos-activos","status":"publish","type":"post","link":"https:\/\/www.linseis.com\/pt-pt\/conhecimentos\/analise-termica-simultanea-para-a-caraterizacao-de-ingredientes-farmaceuticos-activos\/","title":{"rendered":"An\u00e1lise t\u00e9rmica simult\u00e2nea para a carateriza\u00e7\u00e3o de ingredientes farmac\u00eauticos activos"},"content":{"rendered":"\t\t<div data-elementor-type=\"wp-post\" data-elementor-id=\"105918\" class=\"elementor elementor-105918 elementor-105587\" data-elementor-post-type=\"post\">\n\t\t\t\t<div class=\"elementor-element elementor-element-7926ba2 e-flex e-con-boxed e-con e-parent\" data-id=\"7926ba2\" data-element_type=\"container\" data-e-type=\"container\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t<div class=\"elementor-element elementor-element-127df63 e-con-full e-flex e-con e-child\" data-id=\"127df63\" data-element_type=\"container\" data-e-type=\"container\">\n\t\t\t\t<div class=\"elementor-element elementor-element-8f8b21d elementor-toc--minimized-on-tablet elementor-widget elementor-widget-table-of-contents\" data-id=\"8f8b21d\" data-element_type=\"widget\" data-e-type=\"widget\" data-settings=\"{&quot;headings_by_tags&quot;:[&quot;h2&quot;],&quot;exclude_headings_by_selector&quot;:[],&quot;no_headings_message&quot;:&quot;No headings were found on this page.&quot;,&quot;marker_view&quot;:&quot;numbers&quot;,&quot;minimize_box&quot;:&quot;yes&quot;,&quot;minimized_on&quot;:&quot;tablet&quot;,&quot;hierarchical_view&quot;:&quot;yes&quot;,&quot;min_height&quot;:{&quot;unit&quot;:&quot;px&quot;,&quot;size&quot;:&quot;&quot;,&quot;sizes&quot;:[]},&quot;min_height_tablet&quot;:{&quot;unit&quot;:&quot;px&quot;,&quot;size&quot;:&quot;&quot;,&quot;sizes&quot;:[]},&quot;min_height_mobile&quot;:{&quot;unit&quot;:&quot;px&quot;,&quot;size&quot;:&quot;&quot;,&quot;sizes&quot;:[]}}\" data-widget_type=\"table-of-contents.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<div class=\"elementor-toc__header\">\n\t\t\t\t\t\t<h4 class=\"elementor-toc__header-title\">\n\t\t\t\t\u00cdndice\t\t\t<\/h4>\n\t\t\t\t\t\t\t\t\t\t<div class=\"elementor-toc__toggle-button elementor-toc__toggle-button--expand\" role=\"button\" tabindex=\"0\" aria-controls=\"elementor-toc__8f8b21d\" aria-expanded=\"true\" aria-label=\"Open table of contents\"><svg aria-hidden=\"true\" class=\"e-font-icon-svg e-fas-chevron-down\" viewBox=\"0 0 448 512\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\"><path d=\"M207.029 381.476L12.686 187.132c-9.373-9.373-9.373-24.569 0-33.941l22.667-22.667c9.357-9.357 24.522-9.375 33.901-.04L224 284.505l154.745-154.021c9.379-9.335 24.544-9.317 33.901.04l22.667 22.667c9.373 9.373 9.373 24.569 0 33.941L240.971 381.476c-9.373 9.372-24.569 9.372-33.942 0z\"><\/path><\/svg><\/div>\n\t\t\t\t<div class=\"elementor-toc__toggle-button elementor-toc__toggle-button--collapse\" role=\"button\" tabindex=\"0\" aria-controls=\"elementor-toc__8f8b21d\" aria-expanded=\"true\" aria-label=\"Close table of contents\"><svg aria-hidden=\"true\" class=\"e-font-icon-svg e-fas-chevron-up\" viewBox=\"0 0 448 512\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\"><path d=\"M240.971 130.524l194.343 194.343c9.373 9.373 9.373 24.569 0 33.941l-22.667 22.667c-9.357 9.357-24.522 9.375-33.901.04L224 227.495 69.255 381.516c-9.379 9.335-24.544 9.317-33.901-.04l-22.667-22.667c-9.373-9.373-9.373-24.569 0-33.941L207.03 130.525c9.372-9.373 24.568-9.373 33.941-.001z\"><\/path><\/svg><\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<div id=\"elementor-toc__8f8b21d\" class=\"elementor-toc__body\">\n\t\t\t<div class=\"elementor-toc__spinner-container\">\n\t\t\t\t<svg class=\"elementor-toc__spinner eicon-animation-spin e-font-icon-svg e-eicon-loading\" aria-hidden=\"true\" viewBox=\"0 0 1000 1000\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\"><path d=\"M500 975V858C696 858 858 696 858 500S696 142 500 142 142 304 142 500H25C25 237 238 25 500 25S975 237 975 500 763 975 500 975Z\"><\/path><\/svg>\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-87bd1e3 elementor-widget elementor-widget-spacer\" data-id=\"87bd1e3\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"spacer.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<div class=\"elementor-spacer\">\n\t\t\t<div class=\"elementor-spacer-inner\"><\/div>\n\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-746ad39 elementor-widget elementor-widget-text-editor\" data-id=\"746ad39\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p>A ind\u00fastria farmac\u00eautica \u00e9 confrontada com o desafio constante de avaliar com precis\u00e3o a estabilidade e o comportamento t\u00e9rmico de ingredientes farmac\u00eauticos activos. Especialmente para APIs (subst\u00e2ncias farmaceuticamente activas) na forma s\u00f3lida ou cristalina, a an\u00e1lise t\u00e9rmica provou ser uma importante<a href=\"https:\/\/www.linseis.com\/pt-pt\/\" data-auto-event-observed=\"true\" style=\"\">\n  <b> an\u00e1lise t\u00e9rmica<\/b>\n<\/a><a href=\"https:\/\/www.linseis.com\/pt-pt\/\" data-auto-event-observed=\"true\" style=\"\">\n  <b>e<\/b>\n<\/a> estabeleceu-se como uma ferramenta indispens\u00e1vel, uma vez que <a href=\"https:\/\/www.linseis.com\/pt-pt\/?page_id=103578\" data-auto-event-observed=\"true\">\n  <strong>Termogravimetria (TG)<\/strong>\n<\/a> e din\u00e2mica <a href=\"https:\/\/www.linseis.com\/pt-pt\/?post_type=messgeraete&#038;p=103025\" data-auto-event-observed=\"true\">\n  <strong>calorimetria de varrimento diferencial (DSC)<\/strong>\n<\/a> numa \u00fanica etapa de an\u00e1lise. Esta combina\u00e7\u00e3o de m\u00e9todos permite registar simultaneamente altera\u00e7\u00f5es de massa e efeitos calor\u00edficos na mesma amostra, possibilitando a correla\u00e7\u00e3o direta dos resultados sem as incertezas de medi\u00e7\u00f5es separadas. Particularmente quando as quantidades de amostras s\u00e3o limitadas, como \u00e9 frequentemente o caso na investiga\u00e7\u00e3o e desenvolvimento de ingredientes farmac\u00eauticos activos de alta qualidade, o <g id=\"gid_8\">\n  <g id=\"gid_9\">STA<\/g>\n<\/g> permite uma carateriza\u00e7\u00e3o quase completa de sistemas farmac\u00eauticos complexos. Como ambas as an\u00e1lises s\u00e3o realizadas exatamente nas mesmas condi\u00e7\u00f5es &#8211; mesma atmosfera, controlo de temperatura e taxa de aquecimento &#8211; o STA fornece dados altamente reprodut\u00edveis e fi\u00e1veis para o controlo de qualidade e desenvolvimento.    &nbsp;<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-91f5ddb elementor-widget elementor-widget-spacer\" data-id=\"91f5ddb\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"spacer.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<div class=\"elementor-spacer\">\n\t\t\t<div class=\"elementor-spacer-inner\"><\/div>\n\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-32825a9 elementor-widget elementor-widget-heading\" data-id=\"32825a9\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<h2 class=\"elementor-heading-title elementor-size-default\">Identifica\u00e7\u00e3o dos pontos cr\u00edticos de transi\u00e7\u00e3o<\/h2>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-0ae2230 elementor-widget elementor-widget-text-editor\" data-id=\"0ae2230\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p>A <a href=\"https:\/\/www.linseis.com\/pt-pt\/?post_type=messgeraete&#038;p=103967\">\n  <strong>An\u00e1lise T\u00e9rmica Simult\u00e2nea (STA)<\/strong>\n<\/a> \u00e9 um m\u00e9todo chave para identificar pontos cr\u00edticos de transi\u00e7\u00e3o t\u00e9rmica, que s\u00e3o de grande import\u00e2ncia para o desenvolvimento farmac\u00eautico e controlo de qualidade.<\/p><p>Estes pontos de transi\u00e7\u00e3o determinam significativamente as condi\u00e7\u00f5es de processamento e a estabilidade de armazenamento das subst\u00e2ncias farmaceuticamente activas (API).<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-d9546bc elementor-widget elementor-widget-spacer\" data-id=\"d9546bc\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"spacer.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<div class=\"elementor-spacer\">\n\t\t\t<div class=\"elementor-spacer-inner\"><\/div>\n\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-6f1120d elementor-widget elementor-widget-text-editor\" data-id=\"6f1120d\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p><strong>Principais pontos de transi\u00e7\u00e3o:<\/strong><\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-feb266b elementor-widget elementor-widget-spacer\" data-id=\"feb266b\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"spacer.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<div class=\"elementor-spacer\">\n\t\t\t<div class=\"elementor-spacer-inner\"><\/div>\n\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-ad12dcf elementor-widget elementor-widget-text-editor\" data-id=\"ad12dcf\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<ul><li><a href=\"https:\/\/www.linseis.com\/pt-pt\/?p=103232\">\n  <strong>Ponto de fus\u00e3o:<\/strong>\n<\/a> Crucial para o processamento e armazenamento de ingredientes activos.<\/li><li><a href=\"https:\/\/www.linseis.com\/pt-pt\/?p=103212\">\n  <strong>Temperatura de transi\u00e7\u00e3o v\u00edtrea (Tg):<\/strong>\n<\/a> Descreve o intervalo de temperatura no qual as subst\u00e2ncias amorfas ou semi-cristalinas amolecem. Caracteriza o limite acima do qual o aspeto est\u00e1vel e s\u00f3lido se perde e a seguran\u00e7a de armazenamento pode, portanto, ser prejudicada. <\/li><li><strong>Temperatura de decomposi\u00e7\u00e3o:<\/strong> Determina\u00e7\u00e3o precisa da temperatura de in\u00edcio para estabelecer temperaturas est\u00e1veis de processo e armazenamento.<\/li><li><a href=\"https:\/\/www.linseis.com\/pt-pt\/?p=103247\">\n  <strong>Transi\u00e7\u00f5es de fase:<\/strong>\n<\/a> Caracteriza\u00e7\u00e3o de formas cristalinas polim\u00f3rficas com base em temperaturas espec\u00edficas de fus\u00e3o ou de transforma\u00e7\u00e3o.<\/li><\/ul>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-8ccab27 elementor-widget elementor-widget-spacer\" data-id=\"8ccab27\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"spacer.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<div class=\"elementor-spacer\">\n\t\t\t<div class=\"elementor-spacer-inner\"><\/div>\n\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-4ae71fb elementor-widget elementor-widget-text-editor\" data-id=\"4ae71fb\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p>O componente DSC do STA reconhece estas transi\u00e7\u00f5es como picos endot\u00e9rmicos ou exot\u00e9rmicos carater\u00edsticos, enquanto a curva TG documenta as perdas de massa correspondentes. Uma redu\u00e7\u00e3o na <g id=\"gid_0\">\n  <g id=\"gid_1\">temperatura de transi\u00e7\u00e3o v\u00edtrea<\/g>\n<\/g>por exemplo, atrav\u00e9s da absor\u00e7\u00e3o de humidade, pode levar a transforma\u00e7\u00f5es de fase indesejadas ou recristaliza\u00e7\u00e3o. <g id=\"gid_2\">\n  <g id=\"gid_3\">recristaliza\u00e7\u00e3o<\/g>\n<\/g> recristaliza\u00e7\u00e3o. Isto, por sua vez, pode alterar a estrutura cristalina &#8211; com poss\u00edveis consequ\u00eancias, tais como perda de efic\u00e1cia, altera\u00e7\u00e3o da biodisponibilidade ou, no caso mais simples, a necessidade de reclassificar e voltar a rotular a prepara\u00e7\u00e3o.  <\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-e8460c5 elementor-widget elementor-widget-heading\" data-id=\"e8460c5\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<h2 class=\"elementor-heading-title elementor-size-default\">Avalia\u00e7\u00e3o da sensibilidade \u00e0 humidade  <\/h2>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-86c6ec4 elementor-widget elementor-widget-text-editor\" data-id=\"86c6ec4\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p>Muitos ingredientes farmac\u00eauticos activos apresentam um comportamento higrosc\u00f3pico pronunciado, pelo que mesmo pequenas altera\u00e7\u00f5es na humidade relativa podem influenciar significativamente a absor\u00e7\u00e3o de \u00e1gua e, consequentemente, a estabilidade. A <a href=\"https:\/\/www.linseis.com\/pt-pt\/?post_type=messgeraete&#038;p=103967\">\n  <strong>STA<\/strong>\n<\/a> permite uma determina\u00e7\u00e3o quantitativa da perda de humidade por evapora\u00e7\u00e3o ou \u00e1gua de cristaliza\u00e7\u00e3o (1). <\/p><p>A an\u00e1lise da sensibilidade \u00e0 humidade inclui v\u00e1rios par\u00e2metros cr\u00edticos que s\u00e3o essenciais para a avalia\u00e7\u00e3o da estabilidade. A adsor\u00e7\u00e3o e a dessor\u00e7\u00e3o de \u00e1gua tornam-se vis\u00edveis no sinal TG como altera\u00e7\u00f5es discretas de massa, enquanto as altera\u00e7\u00f5es de calor ou temperatura que as acompanham permitem tirar conclus\u00f5es sobre a forma de liga\u00e7\u00e3o da \u00e1gua.   <\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-5892926 elementor-widget elementor-widget-spacer\" data-id=\"5892926\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"spacer.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<div class=\"elementor-spacer\">\n\t\t\t<div class=\"elementor-spacer-inner\"><\/div>\n\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-a91c7c5 elementor-widget elementor-widget-text-editor\" data-id=\"a91c7c5\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p><strong>Par\u00e2metros de avalia\u00e7\u00e3o importantes:  <\/strong><\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-e6a997e elementor-widget elementor-widget-spacer\" data-id=\"e6a997e\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"spacer.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<div class=\"elementor-spacer\">\n\t\t\t<div class=\"elementor-spacer-inner\"><\/div>\n\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-c060447 elementor-widget elementor-widget-text-editor\" data-id=\"c060447\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<ul><li>Capacidade de absor\u00e7\u00e3o de \u00e1gua: rela\u00e7\u00e3o entre a quantidade de \u00e1gua absorvida e a massa da amostra  <\/li><li>Teor de humidade de equil\u00edbrio: estado de equil\u00edbrio da humidade em condi\u00e7\u00f5es definidas  <\/li><\/ul><ul><li>Isot\u00e9rmicas de sor\u00e7\u00e3o-dessor\u00e7\u00e3o: Rela\u00e7\u00e3o entre a quantidade de humidade e a humidade relativa  <\/li><\/ul><ul><li>Teor de \u00e1gua cristalina: propor\u00e7\u00e3o de \u00e1gua estruturalmente ligada  <\/li><\/ul><ul><li>Cin\u00e9tica da absor\u00e7\u00e3o de humidade: taxa de absor\u00e7\u00e3o\/liberta\u00e7\u00e3o de \u00e1gua A absor\u00e7\u00e3o de humidade em cristais amorfos de API leva a uma diminui\u00e7\u00e3o da temperatura de transi\u00e7\u00e3o v\u00edtrea, o que pode resultar numa \u00e1rea com maior tend\u00eancia para recristalizar durante o armazenamento ou transporte (2).  <\/li><\/ul>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-80a57bd elementor-widget elementor-widget-spacer\" data-id=\"80a57bd\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"spacer.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<div class=\"elementor-spacer\">\n\t\t\t<div class=\"elementor-spacer-inner\"><\/div>\n\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-e50a5e9 elementor-widget elementor-widget-image\" data-id=\"e50a5e9\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"image.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<img fetchpriority=\"high\" decoding=\"async\" width=\"800\" height=\"450\" src=\"https:\/\/www.linseis.com\/wp-content\/uploads\/2025\/10\/195-1024x576.png\" class=\"attachment-large size-large wp-image-105597\" alt=\"\" srcset=\"https:\/\/www.linseis.com\/wp-content\/uploads\/2025\/10\/195-1024x576.png 1024w, https:\/\/www.linseis.com\/wp-content\/uploads\/2025\/10\/195-300x169.png 300w, https:\/\/www.linseis.com\/wp-content\/uploads\/2025\/10\/195-768x432.png 768w, https:\/\/www.linseis.com\/wp-content\/uploads\/2025\/10\/195.png 1140w\" sizes=\"(max-width: 800px) 100vw, 800px\" \/>\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-f30a374 elementor-widget elementor-widget-heading\" data-id=\"f30a374\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<h2 class=\"elementor-heading-title elementor-size-default\">Decomposi\u00e7\u00e3o t\u00e9rmica e estabilidade de armazenamento<\/h2>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-527dd88 elementor-widget elementor-widget-text-editor\" data-id=\"527dd88\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p>A decomposi\u00e7\u00e3o t\u00e9rmica tem uma influ\u00eancia decisiva na estabilidade de armazenamento de ingredientes farmac\u00eauticos activos, uma vez que pode afetar diretamente a integridade qu\u00edmica e, consequentemente, a efic\u00e1cia. A <a href=\"https:\/\/www.linseis.com\/pt-pt\/?post_type=messgeraete&#038;p=103967\"><strong>An\u00e1lise T\u00e9rmica Simult\u00e2nea (STA)<\/strong> <\/a>permite a identifica\u00e7\u00e3o precoce de tais processos atrav\u00e9s da dete\u00e7\u00e3o simult\u00e2nea de altera\u00e7\u00f5es de massa, bem como de efeitos endot\u00e9rmicos e exot\u00e9rmicos. <\/p><p>Para al\u00e9m da decomposi\u00e7\u00e3o t\u00e9rmica cl\u00e1ssica, <strong>as reac\u00e7\u00f5es de oxida\u00e7\u00e3o<\/strong> podem tamb\u00e9m desempenhar um papel central. Estas conduzem frequentemente a um <g id=\"gid_1\">aumento de massa<\/g>, uma vez que o oxig\u00e9nio \u00e9 incorporado na estrutura molecular. Mesmo uma oxida\u00e7\u00e3o parcial pode alterar a estrutura qu\u00edmica e, assim, prejudicar o efeito farmacol\u00f3gico &#8211; frequentemente muito antes de ocorrer a decomposi\u00e7\u00e3o efectiva.  <\/p><p>Outro fator cr\u00edtico \u00e9 a <strong>desnatura\u00e7\u00e3o<\/strong>: as influ\u00eancias t\u00e9rmicas ou oxidativas fazem com que os ingredientes activos produzidos biotecnologicamente ou \u00e0 base de prote\u00ednas, em particular, percam a sua estrutura nativa. Isto pode levar a uma perda de atividade, \u00e0 forma\u00e7\u00e3o de agregados ou a uma liberta\u00e7\u00e3o alterada, tendo assim um enorme impacto na estabilidade da prepara\u00e7\u00e3o. <\/p><p>A determina\u00e7\u00e3o exacta da <strong>temperatura<\/strong> de <strong>in\u00edcio<\/strong> da decomposi\u00e7\u00e3o ou desnatura\u00e7\u00e3o \u00e9 essencial para a investiga\u00e7\u00e3o e o controlo de qualidade, uma vez que define o limite superior para o armazenamento, transporte e processamento. Mesmo breves excessos podem causar altera\u00e7\u00f5es estruturais irrevers\u00edveis. Com a ajuda do <a href=\"https:\/\/www.linseis.com\/pt-pt\/?post_type=messgeraete&#038;p=103967\">\n  <strong>STA<\/strong>\n<\/a> e da correspondente modela\u00e7\u00e3o cin\u00e9tica, o prazo de validade de uma subst\u00e2ncia medicamentosa tamb\u00e9m pode ser previsto de forma fi\u00e1vel em condi\u00e7\u00f5es de armazenamento definidas.  <\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-52d2ade elementor-widget elementor-widget-spacer\" data-id=\"52d2ade\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"spacer.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<div class=\"elementor-spacer\">\n\t\t\t<div class=\"elementor-spacer-inner\"><\/div>\n\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-a3d7a0a elementor-widget elementor-widget-text-editor\" data-id=\"a3d7a0a\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p><strong>Influencia a estabilidade de armazenamento:<\/strong><\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-165ebb2 elementor-widget elementor-widget-spacer\" data-id=\"165ebb2\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"spacer.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<div class=\"elementor-spacer\">\n\t\t\t<div class=\"elementor-spacer-inner\"><\/div>\n\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-af87035 elementor-widget elementor-widget-text-editor\" data-id=\"af87035\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<ul><li><strong>Degrada\u00e7\u00e3o e perda de efic\u00e1cia:<\/strong> redu\u00e7\u00e3o da concentra\u00e7\u00e3o de ingredientes activos devido a decomposi\u00e7\u00e3o qu\u00edmica ou desnatura\u00e7\u00e3o<\/li><li><a href=\"https:\/\/www.linseis.com\/pt-pt\/?p=103359\">\n  <strong>Oxida\u00e7\u00e3o:<\/strong>\n<\/a> Aumento de massa e altera\u00e7\u00e3o estrutural devido \u00e0 incorpora\u00e7\u00e3o de oxig\u00e9nio<\/li><li><strong>Forma\u00e7\u00e3o de produtos de degrada\u00e7\u00e3o:<\/strong> Forma\u00e7\u00e3o de subprodutos relevantes do ponto de vista qu\u00edmico ou toxicol\u00f3gico<\/li><li><strong>Intera\u00e7\u00e3o com a humidade:<\/strong> Redu\u00e7\u00e3o da estabilidade t\u00e9rmica e poss\u00edveis processos de hidr\u00f3lise com o aumento da humidade<\/li><li><strong>Progn\u00f3stico a longo prazo:<\/strong> previs\u00e3o do prazo de validade em condi\u00e7\u00f5es definidas utilizando a modela\u00e7\u00e3o termocin\u00e9tica<\/li><\/ul>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-abf69aa elementor-widget elementor-widget-spacer\" data-id=\"abf69aa\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"spacer.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<div class=\"elementor-spacer\">\n\t\t\t<div class=\"elementor-spacer-inner\"><\/div>\n\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-02c72d4 elementor-widget elementor-widget-heading\" data-id=\"02c72d4\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<h2 class=\"elementor-heading-title elementor-size-default\">Conclus\u00e3o  <\/h2>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-edec17c elementor-widget elementor-widget-text-editor\" data-id=\"edec17c\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p>A <a href=\"https:\/\/www.linseis.com\/pt-pt\/?p=103359\">\n  <strong>An\u00e1lise T\u00e9rmica Simult\u00e2nea<\/strong>\n<\/a> fornece aos laborat\u00f3rios, investigadores e engenheiros da ind\u00fastria farmac\u00eautica uma ferramenta altamente sens\u00edvel, reprodut\u00edvel e eficiente em termos de tempo. Permite a avalia\u00e7\u00e3o aprofundada e fi\u00e1vel da sensibilidade \u00e0 humidade, transi\u00e7\u00f5es t\u00e9rmicas e processos de decomposi\u00e7\u00e3o de cristais API. Especialmente sob condi\u00e7\u00f5es GMP e no contexto da garantia de qualidade, o STA permite o desenvolvimento e armazenamento de APIs ao mais alto n\u00edvel cient\u00edfico. O m\u00e9todo fornece uma identifica\u00e7\u00e3o precisa dos pontos de transi\u00e7\u00e3o cr\u00edticos, uma avalia\u00e7\u00e3o fi\u00e1vel da sensibilidade \u00e0 humidade e uma carateriza\u00e7\u00e3o completa do comportamento de decomposi\u00e7\u00e3o t\u00e9rmica e qu\u00edmico-estrutural. Isto aumenta significativamente tanto a seguran\u00e7a da an\u00e1lise de ingredientes activos como a efici\u00eancia do desenvolvimento, controlo de qualidade e testes de estabilidade.      <\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-06558f7 elementor-widget elementor-widget-spacer\" data-id=\"06558f7\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"spacer.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<div class=\"elementor-spacer\">\n\t\t\t<div class=\"elementor-spacer-inner\"><\/div>\n\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-227a35e elementor-widget elementor-widget-spacer\" data-id=\"227a35e\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"spacer.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<div class=\"elementor-spacer\">\n\t\t\t<div class=\"elementor-spacer-inner\"><\/div>\n\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-b97a285 elementor-widget elementor-widget-text-editor\" data-id=\"b97a285\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p><strong>Lista de fontes<\/strong> <\/p><p>(1) DocCheck Flexikon: Estabilidade de cristais farmac\u00eauticos.<\/p><p><a href=\"https:\/\/flexikon.doccheck.com\/de\/Stabilit%C3%A4tspr%C3%BCfung_(Pharmazie)\" target=\"_blank\" rel=\"noopener\">https:\/\/flexikon.doccheck.com\/de\/Stabilit%C3%A4tspr%C3%BCfung_(Farm\u00e1cia)<\/a><\/p><p>(2) Deutsche Apotheker Zeitung: Domina as reac\u00e7\u00f5es de decomposi\u00e7\u00e3o.<\/p><p>h<a href=\"https:\/\/www.deutsche-apotheker-zeitung.de\/daz-az\/2015\/daz-52-2015\/zersetzungs-reaktionen-beherrschen\" target=\"_blank\" rel=\"noopener\">ttps:\/\/<\/a>www.deutsche-apotheker-zeitung.de\/daz-az\/2015\/daz-52-2015\/zersetzungs-reaktionen-beherrschen  <\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-0796c93 elementor-widget elementor-widget-spacer\" data-id=\"0796c93\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"spacer.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<div class=\"elementor-spacer\">\n\t\t\t<div class=\"elementor-spacer-inner\"><\/div>\n\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t","protected":false},"excerpt":{"rendered":"<p>A ind\u00fastria farmac\u00eautica enfrenta o desafio constante de avaliar com precis\u00e3o a estabilidade e o comportamento t\u00e9rmico dos ingredientes activos<\/p>\n","protected":false},"author":15,"featured_media":105608,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"inline_featured_image":false,"footnotes":""},"categories":[654],"tags":[],"class_list":["post-105918","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-conhecimentos"],"acf":[],"_links":{"self":[{"href":"https:\/\/www.linseis.com\/pt-pt\/wp-json\/wp\/v2\/posts\/105918","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.linseis.com\/pt-pt\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.linseis.com\/pt-pt\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.linseis.com\/pt-pt\/wp-json\/wp\/v2\/users\/15"}],"replies":[{"embeddable":true,"href":"https:\/\/www.linseis.com\/pt-pt\/wp-json\/wp\/v2\/comments?post=105918"}],"version-history":[{"count":0,"href":"https:\/\/www.linseis.com\/pt-pt\/wp-json\/wp\/v2\/posts\/105918\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.linseis.com\/pt-pt\/wp-json\/wp\/v2\/media\/105608"}],"wp:attachment":[{"href":"https:\/\/www.linseis.com\/pt-pt\/wp-json\/wp\/v2\/media?parent=105918"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.linseis.com\/pt-pt\/wp-json\/wp\/v2\/categories?post=105918"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.linseis.com\/pt-pt\/wp-json\/wp\/v2\/tags?post=105918"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}